Jim Gage

Jim Gage

Company: Asymchem

Job title: CSO


Development and Scale Up of a Fully Continuous Flow Synthesis of 2-Hydroxypyridine-N-Oxide 3:00 pm

A fully continuous-flow synthesis of 2-hydroxypyridine-N-oxide (HOPO), an important peptide coupling reagent used in a variety of pharmaceutical ingredients preparations, was designed, developed, and scaled up The process involves the catalytic oxidation of 2-hydroxypyridine using hydrogen peroxide, followed by quenching and hydrolysis to obtain HOPO in aqueous solution The continuous reaction process and post-treatment process…Read more

day: Day One

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