8:00 am Morning Check-In & Coffee
8:50 am Chair’s Opening Remarks
Maximizing Efficiency and Sustainability: Transformative Techniques in Flow Chemistry
9:00 am Enhancing Sustainability and Efficiency: Innovative Green and Hybrid Techniques in Flow Chemistry
Synopsis
- Delving into the strategic use of flow chemistry to enhance the environmental sustainability of chemical processes, focusing on waste reduction and energy efficiency
- Exploring groundbreaking materials and methods that amplify the environmental benefits of flow chemistry, discussing innovative approaches that push the boundaries of eco-friendly manufacturing practices
- Analyzing the economic and technical factors that drive the adoption of hybrid manufacturing systems, with insight into the seamless integration of traditional batch and innovative flow chemistry processes, forecasting the evolution of the pharmaceutical manufacturing landscape
9:30 am Continuous Flow Chemistry and Data-Rich Experimentation as Enabling Tools to Accelerate Small Molecule Process Development
Synopsis
- Discussing how digital twins and computational modeling can predict process behaviors and outcomes, enhancing planning and risk management for API manufacturing
- Showcasing instances where real-time process analytics and digitalization have directly influenced design choices, improving scale-up efforts and achieving technical milestones
- Exploring the adoption of automated flow chemistry platforms and modular slug flow reactors, which reduce materials use and enable dynamic experiments, thereby accelerating the development of manufacturing routes and optimizing chemical processes
10:00 am Morning Networking Break
Strengthening Industry Collaborations and Safety Standards in Flow Chemistry
11:00 am Enhancing Process Safety and Sustainability in Pharma through Specialty Chemical Practices
Synopsis
- Examining safety measures used in specialty chemicals that could enhance safety protocols in pharmaceutical flow chemistry
- Discussing the integration of environmental sustainability in specialty chemical production and how these practices can be applied to reduce the ecological footprint of pharmaceutical manufacturing
- Assessing the specialty chemical industry’s approach to regulatory challenges, adapting these strategies to meet pharmaceutical standards
11:30 am Roundtable Discussion: Partnering for Success: Forming Strategic Alliances in Flow Chemistry
Synopsis
- Discussing how strategic partnerships with academia, equipment manufacturers, and CDMOs can accelerate flow chemistry projects
- Exploring the criteria for selecting partners and the foundations of successful collaborations
- Showcasing successful partnerships that have led to innovative solutions and commercial products
12:30 pm Networking & Lunch
Enhancing Quality and Efficiency: Advanced Analytical and Simulation Tools in Flow Chemistry
1:30 pm Utilizing PAT Tools in Flow Chemistry to Ensure Consistent Product Quality
Synopsis
- Discussing the integration of Process Analytical Technology (PAT) to monitor and control real-time flow chemistry processes
- Exploring how PAT tools help in understanding reaction mechanisms and kinetics to optimize process conditions
- Showcasing successful applications of PAT in continuous manufacturing setups to enhance product consistency and reduce waste
2:00 pm A Digital Development Approach for Continuous Manufacturing
Synopsis
- Providing Insights into Sanofi’s digital development workflow, covering route selection to manufacturing
- Discussing the benefits of high-fidelity mathematical models and digital shadow as insilico PAT
- Highlighting the ongoing challenges with continuous manufacturing within Sanof
2:30 pm PAT-Enabled Automated Process Control: Application to Otezla Continuous Manufacturing
Synopsis
- Discussing the integration of Process Analytical Technology (PAT) to monitor and control continuous processes in real-time
- Describing a closed-loop control strategy for maintaining optimal operation in response to process disturbances
- Presenting a proof-of-concept demonstration of closed-loop control and highlighting areas for further development