Day Two

Thursday, August 26 2021

12:39 am
Optimization of Reactions & Workups to Accelerate Speed to Market

8:00 am Coffee & Networking

8:45 am Chair’s Opening Remarks

Contrasting Application of Batch vs Flow to Make the Right Decision for Your Process and Shorten Development Times

9:00 am Handling Multi-Step Reactions Using Flow and Batch Processes to Optimize Your Process Development and Manufacturing

  • Andrew Brusoe Principal Scientist, Chemical Development, Boehringer Ingelheim


  • Planning your process development strategy to accommodate both flow and batch processes
  • Harmonizing the switch between batch and flow throughout your process
  • Benefit of using multi-step reactions for your process

9:30 am Session Reserved for Continuus

10:00 am Understanding Key Drivers in Choosing Flow Processes to Streamline Your Process Development


  • Case study: When the chemistry fits better with flow
  • Cost benefits of using flow over batch processes
  • Overall economic benefits of using flow chemistry

10:30 am Morning Refreshments & Networking

Automation and Self-Optimization of Flow Technology to Reduce Overall Turnaround Time

11:30 am Case Study: Pairing Flow Chemistry with Harmonious Emerging Technologies to Reduce Turnaround Time


  • Latest technologies applicable to flow processes
  • Where new technologies will fit into your flow process
  • Is end-to-end automation a possibility?

12:00 pm Session Reserved for Axplora

12:10 pm A Journey Towards Developing an Automated Continuous Flow Platform for the Preparation of Active Pharmaceutical Ingredient Intermediates


  • Integrating the right unit ops for your process and chemistry
  • What is required to achieve automation?
  • Selecting an automation strategy that is fit for purpose

12:40 pm CMAC Data Lab: Cyberphysical Systems and Digital Transformation of CMC


Key topics that will be addressed from CMAC’s research programme:

  • Overview of predictive toolbox development for crystallisation (CCS) and drug product (MCS+)
  • Building the data fabric to support product and process development
  • Datafactories and automated workflows to accelerate development
  • Challenges & opportunities for industrial digital technologies in CMC

1:10 pm Lunch & Networking

Automation and Self-Optimization of Flow Technology to Reduce Overall Turnaround Time

2:10 pm Case Study: Upstream Automation for Reaction Optimization


  • Technologies applicable to the process development and their benefits
  • Appropriate equipment and materials to use
  • Overall strategy to execute an automated development

2:40 pm Applying Automation in Flow Chemistry to Improve Overall Efficiency of Your Process

  • Yuma Miyai Postdoctoral Associate, Massachusetts Institute of Technology


  • Key drivers in introducing automation into flow processes
  • How automation improves capabilities for scale up
  • Why automation of your process improves economies of scale

3:10 pm Round table discussion: Automating the Manufacturing Process for Reaction Optimization


In a round table discussion, the participants discuss the specified topic assigned to
that table

  • Technologies applicable to the manufacturing process and their benefits
  • Reducing turnaround time, labour costs and material waste
  • Integrating automated feedback control systems

3:45 pm Afternoon Refreshments & Networking

Building Relations in Flow Processes: Chemists & Engineers

4:30 pm Building a Flow Process Dream Team: Principles and Practices


  • Distill the principles and practices for building effective teams for flow chemistry process development and manufacturing
  • From the bench to the production suite, flow chemistry presents unique challenges. Equipping teams with the right support and expertise can help to minimize frustration and unlock innovation

5:00 pm Panel Discussion: Coming Together as Chemists and Engineers for Flow


  • What are the most important challenges you face and how do you approach this challenge (question for both chemist and engineer)
  • Discussing different perspectives for common challenges
  • How to structure agreements to set up appropriate incentives for process developers and manufacturers

5:45 pm Chair’s Closing Remarks

6:00 pm Close of Summit