8:00 am Registration & Networking
8:45 am Chair’s Opening Remarks
Choosing Green Chemistry in Flow Processes to Enforce Sustainable Practices in Your Flow Process Development
9:00 am Electrochemistry Capabilities in Process Development
Synopsis
- Scale up electrochemistry to synthesis of 100gram scale builidng block
- Design and optimize electrochemical platform capable of scale up to kilograms
- Advantages and limitations of electro chem in process development
9:30 am Development of a Cryogenic Flow Synthesis and Continuous Extraction Process with Enhanced Yield, Process Control, and Greenness
Synopsis
- Delivery of 250 kg drug substance for a late stage, fast-moving oncology asset via a cryogenic acrylamide flow synthesis and continuous work-up
- Flow reaction was re-engineered on an accelerated timeline to improve greenness, mitigate solubility issues, eliminate potential nitrosamine risk, and improve reaction control during manufacturing
- To selectively remove a key impurity and increase process yield by 10%, a continuous multi-stage counter current extraction was developed, tech transferred, and implemented in manufacturing within a year. High-speed development was achieved through concurrent wet lab and flowsheet modeling efforts
10:00 am Abbvie’s Adventures in Photochemistry and Electrochemistry
Synopsis
- Fundamentals of photochemistry/photoredox • Photoflow reactors and light sources
- Commercialization of photoredox
- Future of photons in pharma
- Electrochemistry in pharmaceuticals
- Electrochemical flow reactors
- Commercial-ready electrochemical flow reactors
- New frontiers in electrochemistry
10:50 am Morning Refreshments & Speed Networking
11:50 am Continuous Green Synthesis of Lomustine
Synopsis
- Optimizing reaction selection using high throughput experimentation
- Mitigating insolubility with mixtures of green solvents
- Continuous reaction polishing before final crystallization using liquid-liquid extractions
Approaching Scale Up of Operations to Streamline Your Drug Development Process
12:20 pm Scalable Synthesis Through Unstable and Energetic Intermediates Enabled by Continuous Flow Technology
Synopsis
- Session details TBC
12:50 pm Round Table Discussion: Approaching Scale Up with Both Process Development and Manufacturing in Mind
Synopsis
- Best strategy to follow to benefit process development and manufacturing
- Maintaining synergy between process development and manufacturing when scaling up
- Modular approaches to flow processes
1:30 pm Lunch & Networking
Beyond Reaction: Working with Waste Materials and Extreme Conditions to Increase Sustainability of Your Flow Process Development
2:30 pm Grand Challenges Within the Chemical Industry Solved by Flow Chemistry: A BASF Perspective
Synopsis
- Challenges for the chemical industry: transforming operations to reach net zero and sustainable production – opportunities of distributed manufacturing
- How to apply flow chemistry in R&D workflows
- Valorization and commercially sustainable flow chemistry
3:00 pm Development and Scale Up of a Fully Continuous Flow Synthesis of 2-Hydroxypyridine-N-Oxide
Synopsis
- A fully continuous-flow synthesis of 2-hydroxypyridine-N-oxide (HOPO), an important peptide coupling reagent used in a variety of pharmaceutical ingredients preparations, was designed, developed, and scaled up
- The process involves the catalytic oxidation of 2-hydroxypyridine using hydrogen peroxide, followed by quenching and hydrolysis to obtain HOPO in aqueous solution
- The continuous reaction process and post-treatment process resulted in >90% isolated yield, with no need for additional separation and purification steps, thus avoiding interruption of the continuous reaction. The scale-up process successfully achieved a production rate of 8 kg/day, making this synthesis method highly suitable for industrial applications.
3:30 pm Exploitation of Mechanochemistry in Order to Minimize Solvent Use
Synopsis
- To what extent do toxic reagents affect your process development
- Advantages of avoiding toxic reagents from the early phases
- Solvent elimination using mechanochemistry in flow
4:00 pm Mastermind Session: Optimal Strategies in Dealing With Wasted Batches and Materials
Synopsis
A Mastermind session is a whole group discussion regarding the highlighted topics
- How do those with inhouse flow processes deal with disposal of waste material
- More sustainable ways of dealing with waste reagents/materials