8:00 am Registration & Networking

8:45 am Chair’s Opening Remarks

Choosing Green Chemistry in Flow Processes to Enforce Sustainable Practices in Your Flow Process Development

9:00 am Electrochemistry Capabilities in Process Development


  • Scale up electrochemistry to synthesis of 100gram scale builidng block
  • Design and optimize electrochemical platform capable of scale up to kilograms
  • Advantages and limitations of electro chem in process development 

9:30 am Development of a Cryogenic Flow Synthesis and Continuous Extraction Process with Enhanced Yield, Process Control, and Greenness


  • Delivery of 250 kg drug substance for a late stage, fast-moving oncology asset via a cryogenic acrylamide flow synthesis and continuous work-up
  • Flow reaction was re-engineered on an accelerated timeline to improve greenness, mitigate solubility issues, eliminate potential nitrosamine risk, and improve reaction control during manufacturing
  • To selectively remove a key impurity and increase process yield by 10%, a continuous multi-stage counter current extraction was developed, tech transferred, and implemented in manufacturing within a year. High-speed development was achieved through concurrent wet lab and flowsheet modeling efforts

10:00 am Abbvie’s Adventures in Photochemistry and Electrochemistry


  • Fundamentals of photochemistry/photoredox • Photoflow reactors and light sources
  • Commercialization of photoredox
  • Future of photons in pharma
  • Electrochemistry in pharmaceuticals
  • Electrochemical flow reactors
  • Commercial-ready electrochemical flow reactors
  • New frontiers in electrochemistry

10:50 am Morning Refreshments & Speed Networking

11:50 am Continuous Green Synthesis of Lomustine


  • Optimizing reaction selection using high throughput experimentation
  • Mitigating insolubility with mixtures of green solvents
  • Continuous reaction polishing before final crystallization using liquid-liquid extractions

Approaching Scale Up of Operations to Streamline Your Drug Development Process

12:20 pm Scalable Synthesis Through Unstable and Energetic Intermediates Enabled by Continuous Flow Technology


  • Session details TBC

12:50 pm Round Table Discussion: Approaching Scale Up with Both Process Development and Manufacturing in Mind


  • Best strategy to follow to benefit process development and manufacturing
  • Maintaining synergy between process development and manufacturing when scaling up
  • Modular approaches to flow processes

1:30 pm Lunch & Networking

Beyond Reaction: Working with Waste Materials and Extreme Conditions to Increase Sustainability of Your Flow Process Development

2:30 pm Grand Challenges Within the Chemical Industry Solved by Flow Chemistry: A BASF Perspective


  • Challenges for the chemical industry: transforming operations to reach net zero and sustainable production – opportunities of distributed manufacturing
  • How to apply flow chemistry in R&D workflows
  • Valorization and commercially sustainable flow chemistry

3:00 pm Building a Broad-Based Toolkit to Promote Flow Processing: Development and Implementation of a Fully Continuous Flow Synthesis of 2-Hydroxypyridine-N-Oxide and Other Adventures


  • A fully continuous-flow synthesis of 2-hydroxypyridine-N-oxide (HOPO), an important peptide coupling reagent used in a variety of pharmaceutical ingredients preparations, was developed and implemented in production, an effort accelerated by 3D-printing capabilities.
  • The talk will also describe several recent applications of enzyme immobilization to enable flow versions of biocatalytic processes.

3:30 pm Exploitation of Mechanochemistry in Order to Minimize Solvent Use


  • To what extent do toxic reagents affect your process development
  • Advantages of avoiding toxic reagents from the early phases
  • Solvent elimination using mechanochemistry in flow

4:00 pm Mastermind Session: Optimal Strategies in Dealing With Wasted Batches and Materials


A Mastermind session is a whole group discussion regarding the highlighted topics

  • How do those with inhouse flow processes deal with disposal of waste material
  • More sustainable ways of dealing with waste reagents/materials

4:30 pm Afternoon Refreshments & Poster Session

5:30 pm Chair’s Closing Remarks

5:45 pm Close of Day 1