Building a Broad-Based Toolkit to Promote Flow Processing: Development and Implementation of a Fully Continuous Flow Synthesis of 2-Hydroxypyridine-N-Oxide and Other Adventures

Time: 3:00 pm
day: Day One


  • A fully continuous-flow synthesis of 2-hydroxypyridine-N-oxide (HOPO), an important peptide coupling reagent used in a variety of pharmaceutical ingredients preparations, was developed and implemented in production, an effort accelerated by 3D-printing capabilities.
  • The talk will also describe several recent applications of enzyme immobilization to enable flow versions of biocatalytic processes.