8:30 am Breakfast Interactive Deep Dive: Technology & Process Design

10:30 am Chair’s Opening Remarks

  • C. Oliver Kappe Professor, Scientific Director, University of Graz, Center for Continuous Flow Synthesis & Processing (CC FLOW)

Enabling Photo- & Electro-Chemistry Unlocking an Invigorated Pipeline

10:40 am Innovation in Photocatalysis Through Use of Microreactor Technology

  • Timothy Noël Full Professor, Chair of Flow Chemistry Van ‘t Hoff Institute for Molecular Sciences, University of Amsterdam


  • New synthetic methodology developed in our group which benefits from flow chemistry
  • Scale-up using spinning disk reactor technology
  • Solar photochemistry – how LSC-based photoreactors can harvest solar energy for photochemical processes

11:10 am Electrifying API Synthesis Using Continuous Flow Reactors

  • David Cantillo Assistant Professor Research Center Pharmaceutical Engineering GmbH (RCPE), University of Graz


  • Greener methods for API synthesis using electrochemistry
  • Electrochemical reaction discovery, optimization and intensification
  • Translation of electrochemical processes to scalable flow cells

11:40 am Virtual Speed Networking


Get matched with a fellow attendee or speaker for an introductory chat – click to exchange virtual business cards and expand your flow chemistry network

Hydrogenation & Catalysis for a Green Approach

12:10 pm Development of Continuous hydrogenation Processes & Scale-up for Pharmaceutical Intermediates


  • Advantages of continuous hydrogenation
  • Example of homogenous hydrogenation
  • Example of heterogenous hydrogenatio

12:40 pm The Role of Real-Time Analytics in Process Understanding of a Catalytic Static Mixer-Enabled Nitro Hydrogenation toward Fenebrutinib

  • René Lebl Post Doctorate Scientist , F. Hoffmann-La Roche


  • Development of a continuous flow hydrogenation process using Catalytic Static Mixer technology
  • Increased process understanding by inline/online reaction monitoring
  • Throughput study up to 175 g product/hour on lab scale with a focus on the impurity profile

1:30 pm Scale-Up of Continuous Hydrogenation Reactions in a Trickle Bed Reactor


  • Selection of suitable catalysts for continuous hydrogenations
  • Characterization work required for successful scale up
  • Trickle bed reactor design

1:40 pm Networking Lunch


Visit the virtual exhibition hall to explore the solutions are partners have on offer, download whitepapers and view bonus videos

2:10 pm Panel Discussion: Selecting the Right Reactor for your Process and Ambitions

  • C. Oliver Kappe Professor, Scientific Director, University of Graz, Center for Continuous Flow Synthesis & Processing (CC FLOW)
  • Paolo Tosatti Senior Scientist, Process Chemistry and Catalysis, F. Hoffmann-La Roche
  • Onkar Manjrekar Senior Scientist , AbbVie
  • Jennifer Groh Associate Sr Consultant Engineer Synthetic Molecule Design and Development, Eli Lilly and Company
  • Lee Edwards Investigator, Associate Fellow, Primary Continuous Manufacturing, GSK


  • Packed-Bed vs Catalyst-Coated Reactors in Hydrogenation: What are relative benefits of each technology?
  • What is the potential for scale up and how to achieve selectivity?
  • CSTR vs PFR: Again, how do we strike the balance between reaction rate and selectivity? Which reactor best fits which processes and what is more accessible in biotech, academia, and large pharma?

3:00 pm Enabling Flow Chemistry Through Process Optimization

  • Brenden Lee Director, Business Development, Birdotech


  • Balancing existing know-to between batch reactions and flow chemistry processes
  • Changing minds and hearts to enable production scale capabilities
  • Continuous process improvements vs. time constraints

3:15 pm

Afternoon Tea and Networking

Exploiting Flow Chemistry Flexibility

3:45 pm Flow and the COVID-19 Test Kit


  • Flowing LAH in large scale
  • Reactor design to accommodate solids and off-gassing
  • Implementing sampling, PAT and AI in flow

4:15 pm From COVID to Canals: Cautionary Tales of Centralized Pharmaceutical Manufacturing

  • Luke Rogers Vice President, Innovation , On Demand Pharmaceuticals


  • As both the cost and supply gap in medicine are increasing, there are on average 200 drug shortages each year, creating an unmet need for patients
  • APIs traditionally have long batch synthesis and supply chains, leading to inflated capital and operating expenditure, a shift towards continuous manufacturing may be the answer. Whilst the benefits of flow chemistry is well know, the present challenge is now the implementation of an end-to-end manufacturing strategy that can allow these methodologies to work in concert, in a streamlined manner that enables drug substance and drug product production in one manufacturing platform
  • We will discuss how ODP have utilized substantial advances in complex reaction telescoping, real time formulation, reaction engineering and pumping technologies, have enabled the design, construction and implementation of compact and reconfigurable platforms

4:45 pm Round Table Discussion: Harnessing Flow Chemistry in Pandemic Response


  • From testing kits to vaccine manufacturing – how can pharma utilize the flexible scale up of flow chemistry to respond to current and future pandemics?
  • Incorporation of mRNA into lipid nanoparticles can be a bottle neck for vaccine manufacturing, could this step be made more efficient with flow chemistry?
  • Round table discussions make the most out of the conference platform interactivity. Share your audio and video to get involved in group discussion on hot topics and share your perspective

5:10 pm Implementation of Continuous Processing for the Manufacture of Synthetic Peptides

  • Jennifer Groh Associate Sr Consultant Engineer Synthetic Molecule Design and Development, Eli Lilly and Company


• Continuous manufacturing was employed as a component of the hybrid solid phase peptide synthesis (SPPS)/ liquid phase peptide synthesis (LPPS) of tirzepatide to allow for superior quality control and reduced manufacturing risk
• The scale-up and integration of process analytical technology will be discussed.
• Implementation of the strategy worked well resulting in a robust process with high yields and purity

5:30 pm Close of Day 1

5:45 pm Closing Remarks