8:00 am Morning Check-In & Coffee

8:45 am Chair’s Opening Remarks

Revolutionizing Synthesis: Electrochemistry Photochemistry, Flow Chemistry

9:00 am Integrating Electrochemistry in Flow Chemistry for Enhanced Process Economics

Synopsis

  • Exploring the implementation of electrochemical methods to achieve cost-effective and scalable synthesis, enhancing production efficiencies
  • Discussing the integration of electrochemical reactors in flow systems to enhance safety and environmental sustainability, optimizing chemical processes
  • Showcasing real-world applications where electrochemistry has revolutionized process efficiency and product quality

9:30 am Optimizing Project Selection for Flow Chemistry Implementation

  • Ravendra Singh Director - Pharmaceutical Systems Engineering Faculty, Rutgers University

Synopsis

  •  Identifying key project characteristics that benefit most from flow chemistry, focusing on cryogenic conditions and rapid reactions
  • Analyzing case studies where flow chemistry provided significant advantages in impurity control and product stability
  • Establishing guidelines to help decision-makers choose flow chemistry applications wisely

10:00 am Session Reserved for Continuus

10:30 am Morning Break & Speed Networking

Synopsis

Our speed networking session provides a dynamic and efficient platform for flow chemistry professionals to expand their network, exchange insights, discover opportunities, and foster meaningful connections within the flow chemistry industry

Strategic Integration and Excellence in Flow Chemistry: Decision-Making, Project Optimization, and Capability Development

11:30 am A Perspective on Late-Stage API Process Development: Philosophy and Strategy for Implementing Continuous Manufacturing

Synopsis

  • Perspectives on late-stage process development and the challenges of transitioning API processes, with or without continuous manufacturing, from development to commercialization
  • Examining the underappreciated opportunities for continuous manufacturing in latestage process development
  • Exploring strategies to achieve organizational alignment to implement continuous manufacturing in late-stage API process development

12:00 pm Strategic Decisions in Flow Chemistry Adoption: When and How?

  • Sean Kelly Senior Scientist - Synthetic Molecules Process Chemistry, Genentech

Synopsis

Providing a robust decision-making framework to assist chemists and engineers in selecting between traditional batch processes and innovative flow chemistry techniques for increased efficiency

Discussing strategic considerations for adopting flow chemistry, including technical suitability, cost implications, and potential returns

Exploring the pivotal role of process chemists in advocating for the adoption of new technologies within pharmaceutical companies

12:30 pm Lunch & Networking

Mastering Scale-Up in Flow Chemistry: From Lab Bench to Commercial Viability

1:30 pm Panel Discussion: Overcoming Scale-Up Challenges in Flow Chemistry: From Lab to Industry

Synopsis

  • Discussing common pitfalls and strategies for scaling flow chemistry processes from the laboratory to full-scale production, ensuring smoother transitions
  • Exploring the technical and logistical aspects of transferring flow chemistry processes to manufacturing settings, emphasising continuity and scalability
  • Showcasing examples where scale-up challenges were successfully addressed, for commercial success and operational excellence

2:30 pm Advancing Process Efficiency: Transitioning Grignard Reactions from Batch to Flow Chemistry

  • Yihui Yang Senior Staff Engineer, Takeda Pharmaceutical

Synopsis

  • Enhancing system reliability: encountering initial failures due to sensitive batch mixing, this challenge prompts exploring flow chemistry to boost reliability and efficiency
  • Showcasing scalable solutions: dedicated process development refines the flow chemistry system, resulting in a successful 6-hour laboratory demonstration that highlights the potential for scalability and robust performance
  • Advancing technology transfer: successfully transferring and scaling up the flow process for GMP-compliant operations marks a critical industry milestone, with ongoing efforts focusing on optimizing the process for continuous improvement

3:00 pm Afternoon Networking Break & Poster Session

4:00 pm The Journey from Empty Labs to Commercial Production in Five Years

Synopsis

  • Exploring modular, multi-purpose hardware and automation concepts to speed up the transition from empty labs to commercial production within five years
  • Showcasing examples where continuous processing has enabled reliable clinical and commercial supply chains
  • Outlining challenges and solutions encountered when transferring flow chemistry processes to pilot setups, enhancing scalability and efficiency

4:30 pm Roundtable Discussion: Navigating Regulatory Landscapes for Flow Chemistry in Pharmaceutical Manufacturing

Synopsis

  • Discussing regulatory considerations and challenges when implementing flow chemistry for pharmaceutical applications, emphasizing the need for compliance and adaptability
  • Exploring strategies for successful regulatory submissions that involve novel manufacturing techniques, aiming to expedite approval processes and market entry
  • Examining the impact of regulatory guidance on the design and operation of flow chemistry processes, ensuring that these innovations meet current and future standards

5:15 pm Chair’s Closing Remarks

5:30 pm End of Conference Day One