Martin Johnson

Martin Johnson

Company: Eli Lily

Job title: Chemical Engineer


cGMP Manufacturing Aspects of API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection 9:00 am

• Plant throughput kg/h was 200X larger than development scale. Run time in the plant was 7X longer than in development. There was no startup transition waste for the continuous evaporation, crystallization, and semi-continuous filtration sections. Stop/restart was done 17 times with no diverting to waste • Surge drums decoupled the upstream chemistry CM sections…Read more

day: Day Two

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