David Snead
Company: Mirati Therapeutics
Job title: Associate Director, Chemical Development
Seminars:
Afternoon Chair’s Closing Remarks 4:00 pm
day: Day One
Enabling Atroposelective Syntheses via Simultaneous Processing of Antagonistic Chemical Events (SPACE) 10:00 am
• Optical resolution is a reliable method for separation of atropisomers but it is plagued by a maximum-yield of 50% • Axes of chirality can be thermally epimerized but this conflicts with conditions required for crystallization (cooling) • Continuous flow can be applied to resolve these competing needs, resulting in high-yielding synthesis of atropisomers which…Read more
day: Day One