Enabling Atroposelective Syntheses via Simultaneous Processing of Antagonistic Chemical Events (SPACE)

Time: 10:00 am
day: Day One


• Optical resolution is a reliable method for separation of atropisomers but it is
plagued by a maximum-yield of 50%
• Axes of chirality can be thermally epimerized but this conflicts with conditions
required for crystallization (cooling)
• Continuous flow can be applied to resolve these competing needs, resulting in
high-yielding synthesis of atropisomers which in turn reduces consumption of
solvent and valuable chemical intermediates